[Clinicopathological features of angioimmunoblastic T-cell lymphoma pattern Ⅰ]

Area of Science:

• Hematopathology
• Oncology
• Immunology

Background:

• Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive non-Hodgkin lymphoma.
• AITL Pattern Ⅰ presents unique diagnostic challenges.
• Accurate diagnosis is critical for appropriate patient management.

Purpose of the Study:

• To investigate the clinicopathological features of AITL Pattern Ⅰ.
• To identify key diagnostic markers for AITL Pattern Ⅰ.
• To improve diagnostic accuracy for this specific lymphoma subtype.

Main Methods:

• Retrospective analysis of 11 AITL Pattern Ⅰ cases.
• Evaluation of clinicopathological data, including immunophenotype and Epstein-Barr virus (EBV) status.
• Testing of T cell receptor (TCR) clonality and histological morphology.

Main Results:

• AITL Pattern Ⅰ cases exhibited specific histological findings, including hyperplastic follicles and atypical lymphocytes.
• Immunohistochemistry revealed characteristic expression patterns of CD3, CD4, PD-1, CXCL13, ICOS, and CD10.
• All cases showed monoclonal T cell receptor gene rearrangement and scattered EBV-encoded small RNA (EBER) positive B lymphocytes.

Conclusions:

• Diagnosing AITL Pattern Ⅰ requires a multidisciplinary approach.
• Integration of clinical, histological, immunophenotypic, and molecular data is essential.
• This study highlights the complexity and diagnostic criteria for AITL Pattern Ⅰ.