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Serum-soluble ST2 and systemic sclerosis arthropathy.

Amalia Colalillo1, Chiara Pellicano1, Edoardo Rosato2

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Summary

Elevated soluble ST2 (sST2) serum levels in systemic sclerosis patients correlate with increased joint disease activity, tendon friction rubs, and hand dysfunction. These findings suggest sST2 plays a role in systemic sclerosis articular involvement.

Keywords:
IL33JointSystemic sclerosisTendon friction rubssST2

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Area of Science:

  • Rheumatology and Immunology
  • Molecular Biology
  • Biochemistry

Background:

  • Interleukin-33 (IL33) and its receptor ST2 are implicated in inflammatory conditions like arthritis.
  • Systemic sclerosis (SSc) is a complex autoimmune disease characterized by fibrosis and vascular abnormalities, often involving articular structures.

Purpose of the Study:

  • To investigate the association between serum levels of IL33 and soluble ST2 (sST2) and articular involvement in patients with systemic sclerosis.
  • To determine if IL33 or sST2 levels correlate with disease activity and specific clinical manifestations of joint involvement in SSc.

Main Methods:

  • Serum samples from 64 SSc patients and 24 healthy controls (HC) were analyzed for IL33 and sST2 levels.
  • Articular involvement was assessed using the Disease Activity Score 28 (DAS28-ESR), presence of tendon friction rubs (TFRs), and finger-to-palm (FTP) distance.
  • Statistical analyses, including correlation and comparison tests, were performed to evaluate associations.

Main Results:

  • Significantly higher sST2 serum levels were observed in SSc patients with higher DAS28-ESR scores (DAS28-ESR > 3.2), presence of TFRs, and reduced FTP distance (FTP ≥ 1 cm).
  • A positive linear correlation was found between sST2 levels and DAS28-ESR, as well as the Disease Activity Index and Disease Severity Scale.
  • No significant association was found between IL33 serum levels and the assessed parameters of articular involvement.

Conclusions:

  • Elevated serum sST2 levels are associated with increased articular disease activity, TFRs, and hand dysfunction in SSc patients.
  • These findings suggest a potential role for sST2 in the pathogenesis of articular manifestations in systemic sclerosis.
  • sST2 may serve as a potential biomarker for joint involvement in SSc.