Related Experiment Video

Updated: Aug 29, 2025

Generation of Heterogeneous Drug Gradients Across Cancer Populations on a Microfluidic Evolution Accelerator for Real-Time Observation
10:24

Generation of Heterogeneous Drug Gradients Across Cancer Populations on a Microfluidic Evolution Accelerator for Real-Time Observation

Published on: September 19, 2019

6.5K

Heterogeneous run-and-tumble motion accounts for transient non-Gaussian super-diffusion in haematopoietic

Benjamin Partridge1, Sara Gonzalez Anton2,3, Reema Khorshed2

  • 1Department of Bioengineering, Imperial College London, South Kensington Campus, London, United Kingdom.

Plos One
|September 13, 2022
PubMed

Insights

Multi-potent progenitor (MPP) cells exhibit transient super-diffusion, a finding explained by a run-and-tumble motion model. This research estimates the transition from super-diffusion to Fickian diffusion, highlighting motility

Area of Science:

  • Hematology
  • Cell Biology
  • Biophysics

Background:

  • Multi-potent progenitor (MPP) cells are crucial intermediates linking hematopoietic stem cells to mature blood cells.
  • MPP cell fate is influenced by migration between distinct spatial niches.
  • Understanding MPP cell dynamics is key to comprehending early hematopoietic development.

Purpose of the Study:

  • To statistically analyze MPP cell trajectory data from in vivo imaging.
  • To model MPP cell motion and explain observed super-diffusion.
  • To predict the transition from super-diffusion to Fickian diffusion at extended timescales.

Main Methods:

  • Long time-course 3D in vivo imaging of MPP cells in irradiated mouse calvaria.
  • Statistical analysis of cell trajectory data.
  • Development and application of a run-and-tumble cell motion model.

Main Results:

  • MPP cells exhibit transient super-diffusion with non-Gaussian displacement distributions.
  • A run-and-tumble model successfully explains the observed heterogeneous MPP dynamics.
  • Model extrapolation estimates the timescale for super-diffusion to transition to Fickian diffusion.

Conclusions:

  • Cellular motility plays a significant role in the function of early hematopoietic progenitors.
  • The run-and-tumble model provides a framework for understanding complex cell migration patterns.
  • This study offers quantitative insights into the diffusion dynamics of MPPs.

More Related Videos

Simultaneous Assessment of Kinship, Division Number, and Phenotype via Flow Cytometry for Hematopoietic Stem and Progenitor Cells10:20

Simultaneous Assessment of Kinship, Division Number, and Phenotype via Flow Cytometry for Hematopoietic Stem and Progenitor Cells

Published on: March 24, 2023

1.7K
In vivo Clonal Tracking of Hematopoietic Stem and Progenitor Cells Marked by Five Fluorescent Proteins using Confocal and Multiphoton Microscopy17:08

In vivo Clonal Tracking of Hematopoietic Stem and Progenitor Cells Marked by Five Fluorescent Proteins using Confocal and Multiphoton Microscopy

Published on: August 6, 2014

13.2K

Related Concept Videos

Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.3K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.2K
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
5.5K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.3K
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:
3.1K