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Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
Published on: April 11, 2018
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Non-neoplastic pathologies mimicking sarcoma - Experience from a tertiary referral centre multidisciplinary team
Faheem Ahmed Malik1, Snehansh Roy Chaudhary2, Nathan Edwards2
1Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
European Journal of Radiology
|September 13, 2022
Summary
A significant number of non-cancerous lesions are misdiagnosed as bone and soft tissue sarcomas. Vascular and inflammatory conditions were the most common tumor-mimicking pathologies referred to a sarcoma multidisciplinary team (MDT).
Area of Science:
- Oncology
- Pathology
- Radiology
Background:
- Distinguishing non-neoplastic lesions from bone and soft tissue tumors is crucial for sarcoma multidisciplinary team (MDT) services.
- Tumor-mimicking pathologies can lead to misdiagnosis and unnecessary treatments.
Purpose of the Study:
- To determine the incidence of non-neoplastic lesions referred to a tertiary sarcoma MDT.
- To analyze the spectrum of these tumor-mimicking pathologies.
Main Methods:
- A retrospective observational study was conducted.
- Biopsy-proven non-neoplastic outcomes of suspected sarcoma cases referred to an MDT over one year were analyzed.
Main Results:
- 8.6% (84/976) of suspected sarcoma referrals were non-neoplastic.
- Vascular (32.1%) and inflammatory (31.0%) conditions were the most common non-neoplastic pathologies.
- Other categories included traumatic, degenerative, and infective pathologies.
Conclusions:
- A notable proportion of referrals to a tertiary sarcoma MDT are non-neoplastic.
- Vascular and inflammatory conditions are the leading causes of tumor-mimicking pathologies.
- This study provides valuable insights into encountered pathologies for clinicians.
