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The microbiota-gut-brain axis in sleep disorders.
Zhe Wang1, Zhong Wang1, Tangsheng Lu2
1Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, 100191, China.
Sleep Medicine Reviews
|September 13, 2022
Summary
The gut microbiota influences sleep regulation, and disruptions in sleep impact gut bacteria. Targeting the gut microbiome may offer new treatments for sleep disorders.
Area of Science:
- Neuroscience
- Microbiology
- Gastroenterology
Background:
- Sleep is vital for physical and mental health, regulated by central and peripheral systems.
- The microbiota-gut-brain axis is increasingly recognized for its role in sleep behavior and disorders.
- Sleep deprivation and sleep disorders are linked to altered gut microbiota composition.
Purpose of the Study:
- To review the bidirectional relationship between sleep and gut microbiota.
- To summarize gut bacteria alterations in various sleep conditions.
- To explore microbiota-gut-brain pathways and microbiota-targeted sleep interventions.
Main Methods:
- Literature review of studies on sleep, gut microbiota, and the microbiota-gut-brain axis.
- Analysis of gut bacteria composition in sleep disturbances and disorders.
- Examination of metabolic, immune, and neural communication routes.
Main Results:
- Sleep deprivation causes gut microbiota dysfunction.
- Sleep disorders are associated with specific changes in gut bacteria.
- The microbiota-gut-brain axis involves metabolic, immune, and neural pathways.
Conclusions:
- The gut microbiota plays a significant role in regulating sleep.
- Abnormal gut microbiota is characteristic of sleep disturbances and disorders.
- Microbiota-targeted interventions show promise for novel sleep disorder treatments.
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