Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Morphogenesis02:19

Morphogenesis

28.7K
Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
28.7K
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

2.2K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
2.2K
Development of the Limb Synovial Joints01:07

Development of the Limb Synovial Joints

1.5K
Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
1.5K
Primary and Secondary Growth in Roots and Shoots03:02

Primary and Secondary Growth in Roots and Shoots

57.7K
Vascular plants, which account for over 90% of the Earth’s vegetation, all undergo primary growth—which lengthens roots and shoots. Many land plants, notably woody plants, also undergo secondary growth—which thickens roots and shoots.
57.7K
Meristems and Plant Growth02:36

Meristems and Plant Growth

46.5K
Plants grow throughout their lives; this is called indeterminate growth, and it distinguishes plants from most animals. Although certain parts of plants stop growing (e.g., leaves and flowers), others grow continuously—like roots and stems.
46.5K
Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

5.5K
The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
5.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A versatile VLP-mediated CRISPR-RNP platform for precise genome editing and durable epigenome silencing in cancer.

Molecular therapy. Nucleic acids·2026
Same author

Isolation and characterization of <i>Pseudarthrobacter cremeus</i> sp. nov. and <i>Ideonella flava</i> sp. nov. from mountain soil.

International journal of systematic and evolutionary microbiology·2026
Same author

Developmental and transcriptional programs that define the initiation of the forelimb.

Development (Cambridge, England)·2026
Same author

The effect of temporary dual artery ligation (TDAL) during laparoscopic myomectomy on reducing intraoperative blood loss: a retrospective cohort study.

European journal of obstetrics, gynecology, and reproductive biology·2026
Same author

Improving Radiology Report Error Detection Using a Multipass Large Language Model: Framework Development and Validation.

JMIR medical informatics·2026
Same author

Phylogenomic Characterization of Hydrogenophaga sedimenti sp. nov. and Larkinella fluvii sp. nov. Isolated from Riverbed Soil.

Current microbiology·2026
Same journal

AXIN1 and AXIN2 regulate the WNT-signaling landscape to promote distinct mesoderm programs.

Developmental cell·2026
Same journal

ARID1A terminates gastric regeneration to prevent cancer.

Developmental cell·2026
Same journal

Myc sustains sex-biased organ zonation in the Drosophila intestine.

Developmental cell·2026
Same journal

Two parallel neuronal circuits involving electrical synapse and DAF-7/TGF-β signaling regulate muscle autophagy in C. elegans.

Developmental cell·2026
Same journal

Menstruation: Once unspoken but now uncovered, one cell type at a time.

Developmental cell·2026
Same journal

The ALS- and FTD-associated proteins annexin A11 and CHMP2B act sequentially in plasma membrane repair.

Developmental cell·2026
See all related articles

Related Experiment Video

Updated: Aug 28, 2025

Application of Impermeable Barriers Combined with Candidate Factor Soaked Beads to Study Inductive Signals in the Chick
08:04

Application of Impermeable Barriers Combined with Candidate Factor Soaked Beads to Study Inductive Signals in the Chick

Published on: November 17, 2016

9.5K

A limb bud morphogen bites the dust.

Hyunji Lee1, Steven A Vokes1

  • 1Department of Molecular Biosciences, University of Texas at Austin, 100 E. 24th Street, Stop A5000, Austin, TX 78712, USA.

Developmental Cell
|September 13, 2022
PubMed
Summary
This summary is machine-generated.

Sonic Hedgehog (SHH) signaling is crucial for limb development. A short SHH exposure initiates digit specification, suggesting it acts as an initiator rather than a morphogen.

More Related Videos

Chicken Recombinant Limbs Assay to Understand Morphogenesis, Patterning, and Early Steps in Cell Differentiation
08:08

Chicken Recombinant Limbs Assay to Understand Morphogenesis, Patterning, and Early Steps in Cell Differentiation

Published on: January 12, 2022

2.3K
Grafting of Beads into Developing Chicken Embryo Limbs to Identify Signal Transduction Pathways Affecting Gene Expression
11:48

Grafting of Beads into Developing Chicken Embryo Limbs to Identify Signal Transduction Pathways Affecting Gene Expression

Published on: January 17, 2016

8.9K

Related Experiment Videos

Last Updated: Aug 28, 2025

Application of Impermeable Barriers Combined with Candidate Factor Soaked Beads to Study Inductive Signals in the Chick
08:04

Application of Impermeable Barriers Combined with Candidate Factor Soaked Beads to Study Inductive Signals in the Chick

Published on: November 17, 2016

9.5K
Chicken Recombinant Limbs Assay to Understand Morphogenesis, Patterning, and Early Steps in Cell Differentiation
08:08

Chicken Recombinant Limbs Assay to Understand Morphogenesis, Patterning, and Early Steps in Cell Differentiation

Published on: January 12, 2022

2.3K
Grafting of Beads into Developing Chicken Embryo Limbs to Identify Signal Transduction Pathways Affecting Gene Expression
11:48

Grafting of Beads into Developing Chicken Embryo Limbs to Identify Signal Transduction Pathways Affecting Gene Expression

Published on: January 17, 2016

8.9K

Area of Science:

  • Developmental biology
  • Molecular signaling

Background:

  • Hedgehog signaling pathways regulate embryonic development.
  • Sonic Hedgehog (SHH) has been traditionally viewed as a morphogen in digit formation.

Purpose of the Study:

  • To investigate the precise role of Sonic Hedgehog (SHH) in digit specification.
  • To determine if SHH functions as a morphogen or an initiator in digit development.

Main Methods:

  • Experimental manipulation of SHH signaling duration during embryonic development.
  • Analysis of digit specification and patterning.

Main Results:

  • A brief exposure to Sonic Hedgehog is sufficient for complete digit specification.
  • The findings challenge the traditional morphogen model for SHH in this context.

Conclusions:

  • Sonic Hedgehog acts as an initiator of digit specification, not a direct morphogen.
  • This revised understanding impacts models of limb development and signaling.