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Applying extrusion-based 3D printing technique accelerates fabricating complex biphasic calcium phosphate-based
Nima Beheshtizadeh1, Mahmoud Azami1, Hossein Abbasi2
1Department of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; Regenerative Medicine Group (REMED), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Journal of Advanced Research
|September 13, 2022
Summary
This review explores biphasic calcium phosphates (BCPs) in bone tissue engineering (BTE) using robocasting. It highlights materials, methods, and challenges for regenerating bone defects.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- Tissue engineering (TE) aims to regenerate damaged organs using the body's mechanisms.
- Bone and cartilage regeneration are critical due to high susceptibility to trauma, tumors, and age-related diseases.
- Novel biomaterials and methods in bone tissue engineering (BTE) are essential for meeting modern healthcare demands.
Purpose of the Study:
- To review materials and methods for biphasic calcium phosphates (BCPs) robocasting in BTE.
- To discuss advancements and challenges in BCP bioink preparation for 3D printing.
- To explore strategies for BCPs in injured bone regeneration.
Main Methods:
- Focus on extrusion-based 3D printing (robocasting) for BCP scaffold fabrication.
- Review of materials and techniques employed in BCP robocasting.
- Analysis of recent advancements in additive manufacturing for bone regeneration.
Main Results:
- BCPs mimic natural bone, promoting cell activity and bone formation.
- Robocasting is a key additive manufacturing technique for BCP scaffolds in BTE.
- Discussion of challenges in bioink additives, post-processing, and clinical applications.
Conclusions:
- BCPs are promising biomaterials for bone regeneration via robocasting.
- Further research is needed on bioink formulation, clinical translation, and biological responses.
- Opportunities exist for optimizing BCP applications in treating bone injuries.
