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Effects of percutaneous coronary intervention on dyspnea in stable coronary artery disease

Michael Wester1, Franziska Koll1, Mark Luedde2

  • 1Department of Internal Medicine II, University Heart Centre Regensburg, University Medical Center Regensburg, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.

Clinical Research in Cardiology : Official Journal of the German Cardiac Society
|September 13, 2022
PubMed

Insights

Percutaneous coronary intervention (PCI) significantly alleviates dyspnea and angina pectoris in stable coronary artery disease (CAD) patients. While PCI improves symptoms, those with pre-existing dyspnea experience less improvement in quality of life.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Clinical Trials

Background:

  • Dyspnea is a common symptom in stable coronary artery disease (CAD).
  • Dyspnea can be an equivalent to angina pectoris in CAD patients.
  • Assessing interventions for dyspnea in CAD is crucial for improving patient outcomes.

Purpose of the Study:

  • To evaluate the impact of percutaneous coronary intervention (PCI) on dyspnea.
  • To assess changes in quality of life and angina pectoris post-PCI in stable CAD patients.
  • To identify predictors of symptomatic improvement after PCI.

Main Methods:

  • Prospective, multi-center PLA-pCi-EBO-pilot trial.
  • 144 patients with symptomatic stable CAD and successful PCI were included.
  • Dyspnea (NYHA scale) and angina (Seattle Angina Questionnaire-SAQ) were assessed 6 months post-PCI.

Main Results:

  • PCI reduced the overall burden of angina pectoris and dyspnea.
  • The prevalence of dyspnea (NYHA class ≥2) decreased from 73% to 54% post-PCI.
  • Patients with initial dyspnea showed less improvement in physical limitation, angina frequency, and quality of life compared to those without dyspnea.

Conclusions:

  • Percutaneous coronary intervention (PCI) is effective in reducing dyspnea in CAD patients.
  • Dyspnea remains a significant challenge, with patients experiencing concomitant dyspnea showing less improvement.
  • Atypical angina pectoris predicted improvement, while diabetes mellitus was associated with a negative outcome.
Abstract

Keywords:
DyspneaPCIPLA-pCi-EBOQoLStable CAD

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