TRIM proteins in hepatocellular carcinoma

Area of Science:

• Biochemistry
• Molecular Biology
• Oncology

Background:

• The tripartite motif (TRIM) protein family comprises conserved E3 ubiquitin ligases with diverse functions.
• TRIM proteins are implicated in various biological processes, including cancer development.
• Their expression in hepatocellular carcinoma (HCC) is modulated by genetic and epigenetic factors.

Purpose of the Study:

• To systematically review the multifaceted roles of TRIM proteins in hepatocellular carcinoma (HCC).
• To elucidate the molecular mechanisms underlying TRIM protein involvement in HCC development and progression.
• To enhance understanding of TRIM proteins as potential therapeutic targets in HCC.

Main Methods:

• Systematic literature review of TRIM proteins in HCC.
• Analysis of TRIM protein structure and function (E3 ligase activity and independent roles).
• Examination of TRIM protein regulation (genetic and epigenetic) in HCC.

Main Results:

• TRIM proteins, acting as E3 ligases, regulate proteasomal degradation of target proteins.
• E3 ligase-independent functions of TRIM proteins are also significant in HCC.
• TRIM proteins influence key hallmarks and signaling pathways critical to HCC progression.

Conclusions:

• TRIM proteins play versatile and critical roles in hepatocellular carcinoma.
• Understanding TRIM protein functions is essential for deciphering HCC pathogenesis.
• TRIM proteins represent promising targets for future HCC therapeutic strategies.