Trace Element Concentration and Cognitive Dysfunction in Elderly Residents in Birjand.

Area of Science:

• Gerontology
• Neuroscience
• Biochemistry

Background:

• Trace elements are implicated in cognitive function modulation.
• Existing research on serum trace elements and cognitive disorders presents conflicting results.

Purpose of the Study:

• To compare serum trace element concentrations between elderly individuals with and without cognitive dysfunction.
• To investigate the association between specific trace elements and cognitive impairment in older adults.

Main Methods:

• A cross-sectional study involving 191 adults over 60 years in Birjand, Iran.
• Assessment of cognitive performance and serum concentrations of aluminum, cobalt, cadmium, chrome, copper, iron, magnesium, manganese, selenium, and zinc.
• Comparison of trace element levels between groups with and without cognitive dysfunction.

Main Results:

• No significant differences were observed in serum concentrations of aluminum, cobalt, chrome, zinc, iron, magnesium, manganese, and selenium.
• Serum copper concentration was significantly elevated in elderly individuals with cognitive dysfunction compared to those with normal cognitive function.

Conclusions:

• The study suggests a potential increase in serum copper in elderly individuals experiencing cognitive dysfunction.
• Findings are limited by a small sample size and cross-sectional design, requiring cautious interpretation.