Related Experiment Video
Updated: Aug 28, 2025
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
18.3K
Central Sensitization in Migraine: A Narrative Review
Keisuke Suzuki1, Shiho Suzuki1, Tomohiko Shiina1
1Department of Neurology, Dokkyo Medical University, Mibu, Japan.
Journal of Pain Research
|September 14, 2022
Summary
Central sensitization (CS) increases neuron responsiveness, causing severe pain from minor stimuli. Managing CS in migraine patients may improve their quality of life.
Area of Science:
- Neuroscience
- Pain Research
- Neurology
Background:
- Central sensitization (CS) involves heightened neuronal responsiveness in the central nervous system.
- CS contributes to chronic pain conditions and neurological disorders.
- Migraine is a debilitating neurological disorder frequently linked to CS.
Purpose of the Study:
- To review the association between central sensitization and migraine.
- To explore the pathophysiological mechanisms linking CS and migraine.
- To examine clinical evidence supporting the role of CS in migraine.
Main Methods:
- Literature review of pathophysiological aspects of CS in migraine.
- Analysis of clinical studies investigating CS and migraine.
- Synthesis of current understanding of CS in migraine pathogenesis.
Main Results:
- CS is implicated in the development of cutaneous allodynia in migraine.
- CS plays a role in the chronification of migraine episodes.
- Evidence supports the link between CS and migraine pathophysiology.
Conclusions:
- Central sensitization is a key factor in migraine development and persistence.
- Screening for and managing CS could enhance migraine patient outcomes.
- Targeting CS may offer new therapeutic strategies for migraine.
Related Concept Videos
01:25Analgesia and Pain Management
763
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
763
01:44Nociception
29.2K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
29.2K
01:22Pathophysiology of Vomiting
1.0K
Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through...
1.0K
01:29Overview of Somatic Sensory Pathways
5.2K
Somatic sensory or somatosensory pathways refer to the neural pathways that carry information related to touch, pressure, pain, temperature, and proprioception from the skin, muscles, tendons, and joints to the brain. These pathways involve several stages of processing and integration of sensory information.
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
5.2K
01:20Pain
588
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
588
01:28Major Somatic Sensory Pathways
1.2K
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
1.2K