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Related Concept Videos

Enzyme-linked Receptors01:00

Enzyme-linked Receptors

Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
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Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
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Demonstration of Proteolytic Activation of the Epithelial Sodium Channel ENaC by Combining Current Measurements with Detection of Cleavage Fragments
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New links for meprin β within the protease web.

Vahap Canbay1, Ulrich Auf dem Keller1

  • 1Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.

The FEBS Journal
|September 14, 2022
PubMed
Summary

Researchers found that meprin β, a metalloprotease, can be shed from cell membranes in unexpected ways. This discovery sheds light on protease networks and their role in skin health and disease.

Keywords:
ADAMMT1-MMPectodomain sheddingepidermismeprinprotease web

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Dermatology

Background:

  • Proteases form complex networks crucial for tissue homeostasis.
  • Disturbances in protease networks can lead to detrimental health consequences.
  • Membrane-anchored sheddases are proteases released via ectodomain shedding.

Purpose of the Study:

  • To investigate the shedding mechanisms of meprin β, a metalloprotease.
  • To understand the role of meprin β in proteolytic networks.
  • To explore the implications for skin homeostasis and inflammatory responses.

Main Methods:

  • Analysis of ectodomain shedding of meprin β.
  • Investigation of proteolytic network interactions.
  • Assessment of meprin β function in relevant biological contexts.

Main Results:

  • Unexpected promiscuity observed in the ectodomain shedding of meprin β.
  • Identification of new links within epidermal protease networks.
  • Meprin β shedding has potential implications for skin homeostasis and injury response.

Conclusions:

  • Meprin β exhibits promiscuous shedding, impacting proteolytic networks.
  • Findings suggest novel connections within the epidermal protease network.
  • This research has implications for understanding skin inflammation, fibrosis, and injury repair.