Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Food Intake01:30

Regulation of Food Intake

333
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
333
CNS Depressants: Alcohol and Nicotine01:27

CNS Depressants: Alcohol and Nicotine

334
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
334
Regulation of Water Intake01:25

Regulation of Water Intake

640
Osmolality refers to the number of solute particles per kilogram of solvent in a solution. Plasma osmolality specifically indicates the total number of solute particles per kilogram of water in blood plasma. This value reflects the body's hydration status and is tightly regulated through mechanisms controlling water intake and output. While water consumption is a conscious decision, the body has intrinsic regulatory systems to maintain fluid balance. Dehydration, a state of water deficit...
640
Neural Regulation of Blood Pressure01:18

Neural Regulation of Blood Pressure

3.3K
The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
3.3K
Neural Regulation01:37

Neural Regulation

39.7K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.7K
Depressants01:28

Depressants

168
Depressant drugs, including alcohol and sedative-hypnotics, diminish central nervous system activity by enhancing the action of gamma-aminobutyric acid (GABA), a neurotransmitter that reduces brain activity and promotes relaxation. These substances can have various therapeutic uses but also pose significant risks, especially when misused or combined.
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...
168

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Towards Mechanism-Informed Treatments for Mental Health.

Journal of neurochemistry·2026
Same author

MDMA alters fear extinction, and reduces alcohol consumption in inbred alcohol preferring iP rats but not outbred Wistar rats.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same author

Chronic alcohol consumption and abstinence disrupt cholinergic gene expression in the mesopontine tegmentum of alcohol-preferring iP rats.

Neuroscience letters·2026
Same author

The Effect of Serotonin 5-HT<sub>2C</sub> Receptor Modulation on Binge Drinking and Alcohol-Seeking in Female Mice.

Addiction biology·2025
Same author

FGF21 analogue PF-05231023 on alcohol consumption and neuronal activity in the nucleus accumbens.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2025
Same author

Midbrain ghrelin receptor signalling regulates binge drinking in a sex specific manner.

Nature communications·2025

Related Experiment Video

Updated: Aug 28, 2025

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
09:26

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

18.9K

How the brain regulates alcohol intake.

Leigh C Walker1, Paulo Pinares-Garcia1, Andrew J Lawrence1

  • 1Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia.

Elife
|September 14, 2022
PubMed
Summary
This summary is machine-generated.

Binge drinking and alcohol use disorder disrupt a key neural pathway crucial for goal-directed behaviors. Understanding this pathway offers new targets for treating alcohol addiction.

Keywords:
alcoholinsulamouseneurosciencestriatumsynaptic plasticity

More Related Videos

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

997
The Motivation for Alcohol Reward: Predictors of Progressive-Ratio Intravenous Alcohol Self-Administration in Humans
05:40

The Motivation for Alcohol Reward: Predictors of Progressive-Ratio Intravenous Alcohol Self-Administration in Humans

Published on: April 28, 2022

3.2K

Related Experiment Videos

Last Updated: Aug 28, 2025

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
09:26

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

18.9K
Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

997
The Motivation for Alcohol Reward: Predictors of Progressive-Ratio Intravenous Alcohol Self-Administration in Humans
05:40

The Motivation for Alcohol Reward: Predictors of Progressive-Ratio Intravenous Alcohol Self-Administration in Humans

Published on: April 28, 2022

3.2K

Area of Science:

  • Neuroscience
  • Behavioral Science
  • Addiction Research

Background:

  • Goal-oriented behaviors are essential for adaptive functioning.
  • The neural circuitry underlying these behaviors is complex and not fully understood.
  • Alcohol use disorder (AUD) is a chronic relapsing brain condition characterized by compulsive alcohol seeking and consumption.

Discussion:

  • Binge drinking and chronic alcohol use disorder (AUD) significantly impact neural pathways.
  • Specifically, the pathway regulating goal-directed behaviors shows dysregulation in AUD.
  • This dysregulation may contribute to the compulsive nature of alcohol seeking and impaired decision-making in AUD.

Key Insights:

  • A specific neural pathway critical for goal-oriented behaviors is identified.
  • This pathway's function is demonstrably impaired by binge drinking and AUD.
  • Dysregulation of this pathway is a potential neurobiological mechanism underlying AUD.

Outlook:

  • Further research into this neural pathway could reveal novel therapeutic targets for AUD.
  • Understanding the precise mechanisms of dysregulation may lead to more effective interventions.
  • This finding opens new avenues for treating alcohol addiction by focusing on behavioral control circuitry.