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Investigating Health Disparities Associated With Multisystem Inflammatory Syndrome in Children After SARS-CoV-2

Laura D Zambrano1, Kathleen N Ly1, Ruth Link-Gelles1,2

  • 1From the COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.

The Pediatric Infectious Disease Journal
|September 14, 2022
PubMed

Insights

Multisystem inflammatory syndrome in children (MIS-C) disproportionately affects minority children. Non-Hispanic Black children and those in high social vulnerability areas face increased MIS-C risk, highlighting disparities in pediatric health outcomes.

Area of Science:

  • Pediatric Infectious Diseases
  • Public Health
  • Epidemiology

Background:

  • Multisystem inflammatory syndrome in children (MIS-C) is a severe complication linked to SARS-CoV-2.
  • MIS-C disproportionately impacts racial and ethnic minority children, indicating significant health disparities.

Purpose of the Study:

  • To investigate risk factors contributing to MIS-C.
  • To understand the underlying causes of MIS-C disparities in children.

Main Methods:

  • A case-control study compared 241 MIS-C cases with 817 SARS-CoV-2-positive controls.
  • Risk factors including race, ethnicity, social vulnerability index (SVI), insurance, and weight-for-age were analyzed.
  • Mixed-effects multivariable logistic regression was employed to assess risk factors.

Main Results:

  • Non-Hispanic Black children had a higher likelihood of MIS-C (aOR: 2.07).
  • Higher SVI tertiles (aOR: 1.88-2.03) and being previously healthy (aOR: 1.64) were independent risk factors.
  • Cases and controls showed similar distributions in sex, age, and U.S. census region.

Conclusions:

  • Non-Hispanic Black children are more prone to developing MIS-C.
  • Further research into immunologic and environmental factors is necessary to explain MIS-C disparities.
Abstract

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