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Renal function damage in children with duplex kidneys.

Qian Lin1, Jiajia Ni2, Yufeng Li3

  • 1Pediatric College, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.

International Urology and Nephrology
|September 14, 2022
PubMed
Summary
This summary is machine-generated.

Children with duplex kidneys often experience impaired renal function, increased urinary tract infections (UTIs), and more severe renal scarring. Split renal function significantly declines in these cases, requiring careful evaluation.

Keywords:
ChildrenDimercaptosuccinic acidDuplex kidneyRenal dynamic imagingSplit renal functionVesicoureteral reflux

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Area of Science:

  • Pediatric Nephrology
  • Urology
  • Medical Imaging

Background:

  • Duplex kidneys are a common congenital anomaly.
  • Associated complications include vesicoureteral reflux (VUR) and urinary tract infections (UTIs).
  • Understanding the impact on renal function is crucial for management.

Purpose of the Study:

  • To assess renal function damage in pediatric patients diagnosed with duplex kidneys.
  • To correlate duplex kidney anatomy with indicators of renal impairment.

Main Methods:

  • Retrospective review of 355 duplex kidneys, 110 UTI kidneys, and 104 VUR kidneys.
  • Analysis of clinical data: age, UTI history, VUR grade, renal scarring, serum creatinine, cystatin C, split renal function (99mTc-DMSA), and effective renal plasma flow (ERPF).

Main Results:

  • Duplex kidneys showed higher VUR grades and renal scarring.
  • Significantly lower split renal function in unilateral duplex kidneys compared to contralateral and control kidneys.
  • Reduced total ERPF in duplex kidneys (left, right, bilateral) versus controls.
  • ERPF was significantly lower in unilateral duplex kidneys compared to contralateral and control kidneys.

Conclusions:

  • Duplex kidneys are associated with increased VUR, renal scarring, and impaired renal function.
  • Split renal function is often significantly reduced in duplex kidneys.
  • Caution is advised when evaluating split renal function in bilateral duplex kidneys.