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Long non-coding RNA colon cancer-associated transcript 2: role and function in human cancers.
Shuoshuo Ma1, Wenjing Wang2, Dengyong Zhang1
1Department of General Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233000, China.
Chinese Medical Journal
|September 14, 2022
Summary
Long non-coding RNA CCAT2 is overexpressed in many tumors, impacting cell behaviors and patient prognosis. This review explores CCAT2's functions and mechanisms in cancer, aiding future clinical applications.
Area of Science:
- Molecular Biology
- Oncology
Background:
- Long non-coding RNAs (lncRNAs) are key regulators of cellular processes, with aberrant expression linked to tumorigenesis.
- Colon cancer-associated transcript 2 (CCAT2) is an oncogenic lncRNA implicated in various cancers beyond colon cancer.
Approach:
- This review synthesizes existing research on the biological functions and molecular mechanisms of CCAT2 in tumor development.
- It examines how CCAT2 influences cancer cell proliferation, migration, epithelial-mesenchymal transition, and apoptosis.
Key Points:
- CCAT2 overexpression is observed in diverse cancers, including liver, lung, breast, and ovarian cancers, and glioma.
- Abnormal CCAT2 expression affects critical biological behaviors through complex mechanisms involving RNA interactions, signaling pathways, and transcriptional regulation.
- CCAT2 levels correlate with tumor progression markers like size, TNM stage, and patient survival, indicating its prognostic potential.
Conclusions:
- LncRNA CCAT2 plays a significant role in multiple tumor types.
- Understanding CCAT2's mechanisms provides a foundation for developing novel cancer diagnostics and therapeutics.
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