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Effect of hydrolyzed formulas on gastrointestinal tolerance in preterm infants: a systematic review and meta-analysis

Mengyuan Li1, Yuehui Fang1, Yiyao Lian1

  • 1Chinese Center for Disease Control and Prevention, National Institute for Nutrition and Health, Beijing, China.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|September 14, 2022
PubMed

Insights

Hydrolyzed formulas (HFs) improve gastrointestinal tolerance in preterm infants by reducing feed intolerance and speeding up full enteral feeding. Standard preterm formulas (SPFs) were less effective in these aspects.

Area of Science:

  • Neonatal Nutrition
  • Gastroenterology
  • Pediatric Clinical Trials

Background:

  • Hydrolyzed formulas (HFs) are increasingly utilized for early enteral nutrition in preterm infants.
  • Assessing the impact of HFs on gastrointestinal tolerance is crucial for optimizing infant feeding protocols.

Conclusions:

  • Hydrolyzed formulas show potential benefits for preterm infants, enhancing gastrointestinal tolerance.
  • HFs may reduce the risk of feed intolerance and accelerate the achievement of full enteral feeding in this vulnerable population.
  • Further research may explore long-term outcomes and specific HF compositions.
Abstract

Keywords:
Preterm infantsfeed intolerancehydrolyzed formulasnecrotizing enterocolitistime to full enteral feeding

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