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Updated: Aug 28, 2025

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Published on: October 24, 2018
Lacosamide Intoxication-induced Wide QRS Tachycardia Successfully Treated with Veno-arterial Extracorporeal Membrane
Chihiro Takai1, Kayo Misumi1,2, Daiki Kaito1
1Department of Emergency and Critical Care, Saiseikai Utsunomiya Hospital, Japan.
Abstract:
Lacosamide is an antiepileptic drug that acts on voltage-gated sodium channels and was approved as an antiepileptic by the Food and Drug Administration in 2008. Although the efficacy and safety of lacosamide have been established in many previous trials, some case reports have shown that it may lead to cardiovascular side effects, especially in patients with electrical conduction system disorders. We herein report a case of life-threatening cardiac arrhythmia caused by lacosamide intoxication that was successfully treated with veno-arterial extracorporeal membrane oxygenation.
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