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Severe Enteritis after Cyclophosphamide Administration in a Patient with Microscopic Polyangiitis: A Case Report and

Shuhei Yoshida1, Jumpei Temmoku1, Tomoyuki Asano1

  • 1Department of Rheumatology, Fukushima Medical University School of Medicine, Japan.

Internal Medicine (Tokyo, Japan)
|September 14, 2022
PubMed

Insights

Severe enteritis is a rare but serious side effect of cyclophosphamide (CPA) therapy. Promptly stopping CPA and providing intensive care is crucial for managing CPA-associated enteritis in patients with gastrointestinal symptoms.

Area of Science:

  • Gastroenterology
  • Pharmacology
  • Oncology

Background:

  • Cyclophosphamide (CPA) is an alkylating agent used in treating various autoimmune diseases and cancers.
  • Severe enteritis is a rare but potentially life-threatening adverse effect of CPA therapy.
  • Only two cases of CPA-induced enteritis were previously documented before this report.

Approach:

  • A case report of a 60-year-old male patient who developed severe enteritis following intravenous CPA for microscopic polyangiitis.
  • Clinical course, imaging, and pathological findings were utilized for diagnosis.
  • A review of all reported cases of CPA-associated enteritis, including the current case, was conducted.

Key Points:

  • The patient presented with severe gastrointestinal symptoms after CPA administration.
  • Diagnosis was confirmed through clinical evaluation, imaging, and histopathology.
  • Successful management involved immediate cessation of CPA and comprehensive supportive care.

Conclusions:

  • Cyclophosphamide-associated enteritis is a critical diagnosis to consider in patients with gastrointestinal distress post-therapy.
  • Early discontinuation of CPA is paramount for patient outcomes.
  • Intensive systemic management and supportive care are essential for recovery.
Keywords:
cyclophosphamideenteritismicroscopic polyangiitis

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