Related Experiment Video

Updated: Aug 28, 2025

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
07:23

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

Published on: August 6, 2021

2.8K

Association between retinal vein occlusion and early-stage hypertension: A propensity score analysis using a large

Yohei Hashimoto1,2, Hidehiro Kaneko3, Shotaro Aso4

  • 1Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. youhashi@m.u-tokyo.ac.jp.

Eye (London, England)
|September 14, 2022
PubMed

Insights

Early-stage hypertension increases the risk of retinal vein occlusion (RVO). This study found elevated blood pressure is linked to higher RVO occurrence, even below traditional hypertension thresholds.

Area of Science:

  • Ophthalmology
  • Cardiology
  • Public Health

Background:

  • The 2017 ACC/AHA guideline lowered hypertension thresholds to 130/80 mmHg.
  • Early-stage hypertension may impact retinal vasculature.
  • Retinal vein occlusion (RVO) is a significant cause of vision loss.

Purpose of the Study:

  • To investigate the association between early-stage hypertension and the occurrence of RVO.
  • To assess RVO risk across different blood pressure categories, including newly defined hypertension stages.

Main Methods:

  • Retrospective cohort study using the JMDC Claims Database (2005-2020).
  • Included individuals with blood pressure (BP) data and no antihypertensive medication use.
  • Classified participants into normal BP, elevated BP, stage 1 hypertension, and stage 2 hypertension groups.
  • Used weighted Cox regression to estimate adjusted hazard ratios for RVO.

Main Results:

  • Over 2.7 million individuals were analyzed with a mean follow-up of 1,091 days.
  • Elevated BP, stage 1, and stage 2 hypertension were associated with significantly increased adjusted hazard ratios for RVO.
  • Hazard ratios for RVO were 1.37, 1.95, and 3.33 for elevated BP, stage 1, and stage 2 hypertension, respectively, compared to normal BP.

Conclusions:

  • Individuals with elevated blood pressure and early-stage hypertension face a higher risk of RVO.
  • The findings support closer monitoring of blood pressure, even in stages previously considered normal or elevated.
  • Lowering hypertension thresholds may identify more individuals at risk for RVO.
Abstract

More Related Videos

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.5K
Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies10:11

Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies

Published on: October 22, 2014

19.2K

Related Concept Videos

Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
41
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
56
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
56
Pre-Procedural Guidelines for Assessing Blood Pressure01:10

Pre-Procedural Guidelines for Assessing Blood Pressure

Accurate blood pressure assessment is crucial for diagnosing and managing various health conditions. To ensure the reliability of these measurements, healthcare professionals must adhere to standardized pre-procedural guidelines. These guidelines enhance patient safety and improve the overall quality of healthcare. The following steps are essential for obtaining accurate and consistent blood pressure readings, from using the appropriate tools to ensuring effective communication with the...
621
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
2.3K
Hypertension IV: Drug Therapy and Lifestyle Modifications01:28

Hypertension IV: Drug Therapy and Lifestyle Modifications

Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...
31