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Related Experiment Videos

Selenium in ischaemic heart disease.

J T Salonen

    International Journal of Epidemiology
    |June 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Low selenium levels may increase the risk of cardiovascular disease (CVD) and ischemic heart disease (IHD). Further research is needed to confirm this association and explore underlying mechanisms.

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    Area of Science:

    • Nutritional epidemiology
    • Cardiovascular research

    Background:

    • Previous studies on selenium (Se) deficiency and ischemic heart disease (IHD) have yielded inconclusive results.
    • Ecological, case-control, and cross-sectional studies suggest a potential link, but are limited by biases and lack of temporal clarity.
    • Existing cohort studies show mixed findings, with some indicating an association and others finding none.

    Purpose of the Study:

    • To investigate the association between serum selenium levels and the risk of cardiovascular events.
    • To address limitations of previous studies, including potential biases and confounding factors.

    Main Methods:

    • Pooled analysis of two eastern Finnish cohorts.
    • Inclusion of participants who experienced a cardiovascular death or non-fatal myocardial infarction and matched event-free controls.

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  • Serum selenium levels were measured and compared between cases and controls.

    • Main Results:

    • Individuals with serum selenium below 45 micrograms/l had a 1.7-fold increased risk of a cardiovascular event.
    • This association was observed in pooled data from 377 cases and 377 matched controls.
    • Potential confounding by other nutrients, such as n-3 polyunsaturated fatty acids, was acknowledged.

    Conclusions:

    • The role of serum selenium in ischemic heart disease remains inconclusive.
    • Further epidemiological studies are warranted to clarify the association.
    • Experimental research is needed to elucidate potential biological mechanisms linking selenium and cardiovascular health.