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Photobiomodulation in 3D tissue engineering
Polina Bikmulina1, Nastasia Kosheleva2,3,4, Anastasia Shpichka2,4
1Sechenov First Moscow State Medical University, World-Class Research Center "Digital Biodesign and Personalized Healthcare", Moscow, Russia, Russia.
Journal of Biomedical Optics
|September 15, 2022
Summary
Photobiomodulation (PBM) enhances cell survival and viability in 3D tissue engineering. This technology offers a promising approach for improving cell health in engineered tissues and scaffolds.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Photomedicine
Background:
- Photobiomodulation (PBM) utilizes light to promote healing and reduce inflammation.
- Effective PBM wavelengths (750-1100 nm) penetrate tissues several centimeters deep.
- PBM applications are expanding into tissue engineering and regenerative medicine.
Purpose of the Study:
- To explore the intersection of PBM and 3D tissue-engineered constructs.
- To identify key areas for PBM application within tissue engineering.
Main Methods:
- Review of PBM history and development.
- Analysis of 3D cultivation system optical properties and light dosimetry.
- Examination of PBM-induced cellular pathways and outcomes in various 3D constructs (hydrogels, scaffolds, spheroids, etc.).
Main Results:
- PBM significantly enhances cell survival and viability in 3D environments.
- Strategies for modulating cell physiology using specific PBM parameters are detailed.
- PBM demonstrates potential for stimulating cellular processes in engineered tissues.
Conclusions:
- PBM is an effective tool for mitigating cellular stress in engineered tissues.
- The convenience of PBM devices makes it suitable for 3D tissue engineering applications.
- 3D tissue engineering represents a promising field for PBM utilization.
