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Author Spotlight: Advancements in Stem Cell Regenerative Therapy Through Photobiomodulation

Author Spotlight: Advancements in Stem Cell Regenerative Therapy Through Photobiomodulation

Published on: April 5, 2024

Photobiomodulation in 3D tissue engineering.

Polina Bikmulina¹, Nastasia Kosheleva^2,3,4, Anastasia Shpichka^2,4

¹Sechenov First Moscow State Medical University, World-Class Research Center "Digital Biodesign and Personalized Healthcare", Moscow, Russia, Russia.

Journal of Biomedical Optics

|September 15, 2022

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Photobiomodulation (PBM) enhances cell survival and viability in 3D tissue engineering. This technology offers a promising approach for improving cell health in engineered tissues and scaffolds.

Area of Science:

Biomedical Engineering
Regenerative Medicine
Photomedicine

Background:

Photobiomodulation (PBM) utilizes light to promote healing and reduce inflammation.
Effective PBM wavelengths (750-1100 nm) penetrate tissues several centimeters deep.
PBM applications are expanding into tissue engineering and regenerative medicine.

Purpose of the Study:

To explore the intersection of PBM and 3D tissue-engineered constructs.
To identify key areas for PBM application within tissue engineering.

Main Methods:

Review of PBM history and development.
Analysis of 3D cultivation system optical properties and light dosimetry.
Examination of PBM-induced cellular pathways and outcomes in various 3D constructs (hydrogels, scaffolds, spheroids, etc.).

Keywords:

low-level light photobiomodulation regenerative medicine tissue engineering

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Main Results:

PBM significantly enhances cell survival and viability in 3D environments.
Strategies for modulating cell physiology using specific PBM parameters are detailed.
PBM demonstrates potential for stimulating cellular processes in engineered tissues.

Conclusions:

PBM is an effective tool for mitigating cellular stress in engineered tissues.
The convenience of PBM devices makes it suitable for 3D tissue engineering applications.
3D tissue engineering represents a promising field for PBM utilization.