Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

971
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
971

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A repeat expansion in GOLGA8A is a major risk factor for atypical frontotemporal lobar degeneration with ubiquitin-positive inclusions.

Nature genetics·2026
Same author

Distinct TAF15 amyloid filament folds define multiple subtypes of FTLD-TAF15.

bioRxiv : the preprint server for biology·2026
Same author

Histopathological Assessment of Cellular Heterogeneity in Pediatric Ependymomas.

Diagnostics (Basel, Switzerland)·2025
Same author

Brain transcriptomics highlight abundant gene expression and splicing alterations in non-neuronal cells in aFTLD-U.

Acta neuropathologica·2025
Same author

Exploring the Role of Hematological Markers and Blood Groups in Breast Cancer Diagnosis.

Clinical laboratory·2025
Same author

An oligodendrocyte silencer element underlies the pathogenic impact of lamin B1 structural variants.

Nature communications·2025

Related Experiment Video

Updated: Aug 28, 2025

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain
12:14

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

Published on: February 12, 2016

35.2K

White matter cellular changes in ischemic injuries.

Murad Alturkustani1,2,3, Lee-Cyn Ang2,3

  • 1Department of Pathology, Faculty of Medicine, King Abdulaziz University Jeddah, Saudi Arabia.

American Journal of Translational Research
|September 15, 2022
PubMed
Summary
This summary is machine-generated.

White matter ischemic changes are not specific. This study details cellular changes in ischemic leukoencephalopathy, identifying axonal swelling and microglial loss as early indicators, aiding diagnosis.

Keywords:
APPHLA-DRinfarctischemic leukoencephalopathywhite matter

More Related Videos

Stereological and Flow Cytometry Characterization of Leukocyte Subpopulations in Models of Transient or Permanent Cerebral Ischemia
12:42

Stereological and Flow Cytometry Characterization of Leukocyte Subpopulations in Models of Transient or Permanent Cerebral Ischemia

Published on: December 28, 2014

15.7K
A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology
08:36

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology

Published on: March 17, 2016

8.2K

Related Experiment Videos

Last Updated: Aug 28, 2025

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain
12:14

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

Published on: February 12, 2016

35.2K
Stereological and Flow Cytometry Characterization of Leukocyte Subpopulations in Models of Transient or Permanent Cerebral Ischemia
12:42

Stereological and Flow Cytometry Characterization of Leukocyte Subpopulations in Models of Transient or Permanent Cerebral Ischemia

Published on: December 28, 2014

15.7K
A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology
08:36

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology

Published on: March 17, 2016

8.2K

Area of Science:

  • Neuropathology
  • Neuroscience
  • Cellular Biology

Background:

  • White matter ischemic changes lack specificity, overlapping with other conditions.
  • Existing literature describes varied morphological features like rarefaction, axonal damage, and myelin degeneration.

Purpose of the Study:

  • To describe the cellular changes in ischemic leukoencephalopathy using immunohistochemical studies.
  • To delineate the morphological spectrum of white matter ischemic injury.

Main Methods:

  • Retrospective study of 24 white matter ischemic injury cases.
  • Review of autopsy reports and selection of representative areas.
  • Immunohistochemical staining including anti-amyloid precursor protein (APP) and anti-human leukocyte antigen (HLA-DR).

Main Results:

  • Early mild injury shows axonal staining (APP+) and astrocytic/microglial reaction.
  • Severe injury leads to complete infarct with macrophage infiltration.
  • Incomplete infarcts exhibit apoptotic nuclei, axonal swelling, clasmatodendrosis, and loss of ramified microglia.

Conclusions:

  • Widespread axonal staining and swelling are early features of ischemic leukoencephalopathy.
  • Loss of HLA-DR positive ramified microglia and astrocytes follow or accompany axonal changes.
  • Understanding this morphological spectrum prevents misdiagnosis and guides future research.