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Long noncoding RNAs as therapeutic targets to overcome chemoresistance in ovarian cancer

Linjiao Chen1, Jie Wang1, Qian Liu1

  • 1Department of Reproductive Medicine, Department of Prenatal Genetics, First Hospital of Jilin University, Changchun, China.

Frontiers in Cell and Developmental Biology
|September 15, 2022
PubMed

Insights

Long noncoding RNAs (lncRNAs) are key in ovarian cancer development and drug resistance. Targeting lncRNAs offers a promising strategy to overcome chemoresistance and improve treatment outcomes for ovarian cancer patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Ovarian cancer is a leading cause of cancer-related deaths in women.
  • Drug resistance significantly limits therapeutic efficacy in ovarian cancer patients.
  • Long noncoding RNAs (lncRNAs) are increasingly recognized for their roles in cancer development.

Purpose of the Study:

  • To review the critical role of lncRNAs in the development of chemoresistance in ovarian cancer.
  • To elucidate the molecular mechanisms underlying lncRNA-mediated drug resistance.
  • To highlight the potential of lncRNAs as therapeutic targets for overcoming chemoresistance.

Main Methods:

  • Literature review of studies investigating lncRNAs in ovarian cancer.
  • Analysis of molecular mechanisms of lncRNA function in chemoresistance.
  • Synthesis of current knowledge on lncRNAs and drug resistance.

Main Results:

  • lncRNAs regulate key cellular processes involved in ovarian tumorigenesis, including proliferation, invasion, apoptosis, and metastasis.
  • Specific lncRNAs are implicated in mediating resistance to various chemotherapeutic agents.
  • Dysregulation of lncRNAs contributes to the complex landscape of ovarian cancer chemoresistance.

Conclusions:

  • lncRNAs play a multifaceted role in ovarian cancer chemoresistance.
  • Understanding lncRNA mechanisms provides insights into overcoming drug resistance.
  • Targeting lncRNAs represents a potential therapeutic strategy to improve treatment responses in ovarian cancer.
Keywords:
chemoresistancecisplatinepigeneticlncRNAovarian cancerpaclitaxeltarget

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