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Related Experiment Video

Updated: Aug 28, 2025

Fabrication of Three-dimensional Paper-based Microfluidic Devices for Immunoassays
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Disposable paper-based microfluidics for fertility testing.

Misagh Rezapour Sarabi1, Defne Yigci2, M Munzer Alseed3

  • 1School of Mechanical Engineering, Koç University, Istanbul, Türkiye 34450.

Iscience
|September 15, 2022
PubMed
Summary
This summary is machine-generated.

Paper-based microfluidic devices offer innovative solutions for fertility testing. These advancements aid in assessing sperm health and improving assisted reproductive technologies (ARTs).

Keywords:
BiodevicesBiotechnologyMedical device in health technology

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Area of Science:

  • Reproductive Medicine
  • Biomedical Engineering
  • Microfluidics

Background:

  • Infertility affects 15% of reproductive-age couples globally, with a higher burden in developing nations.
  • Male factor infertility accounts for 20-30% of cases, often due to suboptimal sperm parameters.
  • Assisted reproductive technologies (ARTs) like IVF and ICSI are vital for overcoming infertility.

Purpose of the Study:

  • To review advancements in paper-based microfluidic devices for fertility testing.
  • To explore their applications in assessing sperm concentration, motility, and DNA integrity.
  • To provide insights into future directions for these microfluidic systems.

Main Methods:

  • Review of fabrication methods for paper-based microfluidic devices.
  • Analysis of current applications in fertility diagnostics.
  • Exploration of emerging technologies and future potential.

Main Results:

  • Microfluidic technologies enable rapid, point-of-care fertility tests.
  • Paper-based devices show promise for assessing key sperm functionalities.
  • Advancements facilitate sperm enrichment and sorting for improved ART outcomes.

Conclusions:

  • Paper-based microfluidics represent a significant advancement in fertility diagnostics.
  • These devices can enhance the effectiveness of assisted reproductive technologies.
  • Future research will likely focus on further refining these systems for widespread use.