Bioinformatics-Based Analysis: Noncoding RNA-Mediated COL10A1 Is Associated with Poor Prognosis and Immune Cell...

Area of Science:

• Oncology
• Molecular Biology
• Genomics

Background:

• Collagen type X alpha 1 (COL10A1) is an extracellular matrix component with aberrant expression in various cancers.
• Its specific role in pancreatic cancer progression remains largely uncharacterized.

Purpose of the Study:

• To investigate the expression patterns and prognostic significance of COL10A1 in pancreatic adenocarcinoma.
• To explore the regulatory mechanisms and immune microenvironment associations of COL10A1 in pancreatic cancer.

Main Methods:

• Utilized TCGA, GEO, and GEPIA databases for expression analysis and prognostic value assessment.
• Analyzed COL10A1 coexpression, functional enrichment, and constructed a ceRNA regulatory axis (TUG1/miR-144-3p/COL10A1).
• Correlated COL10A1 expression with clinical features, immune cell infiltration, and immune checkpoint molecules.

Main Results:

• COL10A1 expression was significantly upregulated in pancreatic cancer tissues.
• High COL10A1 expression correlated with adverse clinicopathological features and poorer patient prognosis.
• The TUG1/miR-144-3p/COL10A1 axis was identified as a key regulatory pathway.
• COL10A1 expression positively correlated with immune cell infiltration and immune checkpoint molecule expression.

Conclusions:

• COL10A1 serves as a potential early diagnostic marker for pancreatic cancer.
• Elevated COL10A1 levels are associated with a poor prognosis and increased immune infiltration in pancreatic cancer.
• The TUG1/miR-144-3p/COL10A1 axis represents a significant regulatory pathway in pancreatic cancer.