Related Experiment Video

Updated: Aug 28, 2025

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
05:51

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness

Published on: May 3, 2018

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Influence of endothelial function and arterial stiffness on the behavior of cervicocephalic arterial dissections: An

Seong-Joon Lee1, Jin Soo Lee1, Min Kim1

  • 1Department of Neurology, Ajou University School of Medicine, Suwon-si, South Korea.

Frontiers in Neurology
|September 15, 2022
PubMed

Insights

Preserved endothelial function aids spontaneous healing in cervicocephalic arterial dissections (CCAD). Increased arterial stiffness is linked to ischemic presentation in CCAD patients.

Area of Science:

  • Vascular Biology and Medicine
  • Cardiovascular Research
  • Neurology and Stroke

Background:

  • Spontaneous cervicocephalic arterial dissections (CCAD) are influenced by arterial wall properties.
  • Endothelial function and arterial stiffness are key mechanical and physiological properties.
  • Assessing these properties may elucidate CCAD behavior and outcomes.

Purpose of the Study:

  • To investigate the impact of endothelial function and arterial stiffness on CCAD clinical characteristics and outcomes.
  • To utilize brachial flow-mediated dilation (FMD) and brachial-ankle pulse wave velocity (PWV) as measures.
  • To correlate FMD and PWV findings with CCAD presentation, healing, and recurrence.

Main Methods:

  • Retrospective analysis of 146 CCAD patients from a single-center database (April 2011 - December 2021).
  • Assessment of endothelial function via brachial flow-mediated dilation (FMD) and arterial stiffness via brachial-ankle pulse wave velocity (PWV).
  • Comparative and multivariable analyses to determine associations between FMD/PWV and clinical outcomes.

Main Results:

  • Normal FMD levels were significantly associated with spontaneous dissection healing (adjusted OR: 4.52).
  • The highest PWV tertile was strongly associated with ischemic stroke presentation (adjusted OR: 17.05).
  • While trends suggested higher recurrence and aneurysmal enlargement in specific PWV groups, frequencies were too low for multivariable analysis.

Conclusions:

  • Preserved endothelial function is a positive predictor of spontaneous arterial healing in CCAD.
  • Increased arterial stiffness, as measured by PWV, is significantly associated with an ischemic presentation in CCAD.
  • These vascular properties offer insights into CCAD pathophysiology and patient risk stratification.
Abstract

Keywords:
arterial stiffnesscervicocephalic arterial dissectionendothelial functionflowmediated dilatationpulse wave velocity

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