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Updated: Aug 28, 2025

Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
Sequence difference of angiotensin-converting enzyme 2 between nonhuman primates affects its binding-affinity with
Xiaojun Zhou1, Jingjing Zhao2, Yefeng Qiu3
1Department of Biosafety, China Biotechnology Co.LTD, Beijing 100025, China.
Abstract:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused many deaths and contributed to a tremendous public health concern worldwide since 2020. Angiotensin-converting enzyme 2 (ACE2) binds to the SARS-CoV-2 virus as a receptor. The challenge of different nonhuman primate (NHP) species by SARS-CoV-2 virus demonstrated different effects on virus replication and disease pathology. This study characterizes differences between host ACE2 sequences of three NHP species: Macaca mulatta, Macaca fascicularis, and Chlorocebus sabaeus. In addition, the binding affinity between the ACE2 ectodomain and the SARS-CoV-2 S receptor-binding domain (RBD) was analyzed. Variation of ACE2 sequence among NHP species and the binding affinity may account for different susceptibility and responses to SARS-CoV-2 infection.
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