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Updated: Aug 28, 2025

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
Androgenic-Anabolic Steroids: From the Gym to Drug-Induced Liver Injury
Ana Sofia Alves1, Sofia Perdigão1, Sandra Morais2
1Internal Medicine, Centro Hospitalar de Trás os Montes e Alto Douro, Chaves, PRT.
Abstract:
Drug-induced liver injury (DILI) is a frequent cause of liver toxicity. We describe the case of a 32-year-old male patient without any relevant past medical history or medication use. In the past two months, he was engaged in weightlifting exercises and consumed androgenic-anabolic steroids to enhance his exercise routine. The patient initially experienced choluria and acholia for two weeks, followed by itching for two days, which led him to present to the emergency room. His laboratory results revealed cytocholestasis. He was admitted for investigations and after excluding other causes of liver injury, the diagnosis of DILI related to the consumption of androgenic-anabolic steroids was made. This case report highlights the perils of using performance-enhancing substances such as androgenic-anabolic steroids, which may lead to severe side effects like DILI.
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