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Analysis of Convalescent Plasma Transfusion in Children Confirmed with COVID-19: A Systemic Review

Casman Casman1, Nurlaila Fitriani2, Deny Gunawan3

  • 1Department of Pediatric Nursing, STIKes RS Husada, Center Jakarta, Indonesia.

Florence Nightingale Journal of Nursing
|September 15, 2022
PubMed

Insights

Convalescent plasma therapy effectively improved clinical outcomes in children with COVID-19. This treatment, administered based on weight, led to good prognoses and recovery for most pediatric patients.

Area of Science:

  • Pediatric Infectious Diseases
  • Hematology
  • Critical Care Medicine

Background:

  • Coronavirus disease-2019 (COVID-19) poses unique challenges in pediatric populations.
  • Convalescent plasma therapy has emerged as a potential treatment modality for severe viral infections.
  • Understanding the efficacy and safety of convalescent plasma in children is crucial for clinical decision-making.

Purpose of the Study:

  • To analyze the effectiveness of convalescent plasma therapy in pediatric patients diagnosed with COVID-19.
  • To investigate the mechanisms of treatment administration and the resulting prognosis following convalescent plasma transfusion.
  • To evaluate the clinical outcomes and recovery rates in children receiving convalescent plasma.

Main Methods:

  • Systematic literature search using keywords: "COVID-19," "convalescent plasma," and "children" or "pediatric."
  • Databases searched included Pubmed, ScienceDirect, Wiley Online, Springerlink, and Ebsco.
  • Selection of 8 low-bias articles adhering to Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines.

Main Results:

  • Convalescent plasma transfusion was administered to 11 pediatric patients with worsening COVID-19 symptoms, including tachypnea and decreased oxygen saturation, requiring intensive care.
  • Dosage of convalescent plasma was determined based on individual child's weight.
  • All 11 children demonstrated a good prognosis post-transfusion, with 7 achieving full recovery and hospital discharge.

Conclusions:

  • Convalescent plasma transfusion is an effective therapeutic intervention for improving the clinical condition of children with COVID-19.
  • Ensuring adherence to proper donor blood protocols is essential for the safe and effective administration of convalescent plasma.
  • This therapy offers a promising option for managing severe COVID-19 cases in pediatric patients.
Abstract

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