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Cannabis dosing and administration for sleep: a systematic review
Rob Velzeboer1, Adeeb Malas2, Pierre Boerkoel3
1Clinical Research, Tranq Sleep Care , Kelowna, British Columbia, Canada.
Sleep
|September 15, 2022
Summary
Cannabis shows some promise for improving sleep, particularly for pain-related disorders. However, high-quality evidence is limited, and specific dosing recommendations for cannabis and sleep are not yet established.
Area of Science:
- Pharmacology
- Sleep Medicine
- Cannabis Research
Background:
- Increasing use of cannabis for sleep disorders.
- Need for evidence-based guidance for prescribers.
- Focus on cannabis dosing for sleep.
Approach:
- A comprehensive search of EMBASE, Medline, and Web of Science was conducted.
- 31 studies were included for analysis, with bias assessed using the Cochrane Risk of Bias tool 2.0.
Key Points:
- Cannabis demonstrated improvements in subjective sleep quality for some participants, especially those with pain-related disorders.
- No significant differences were found between tetrahydrocannabinol and cannabidiol effects on sleep.
- Adverse events like sedation and dizziness were dose-dependent, with no serious events reported.
Conclusions:
- Limited high-quality evidence supports cannabis for sleep.
- Heterogeneity in cannabis products and study designs hinders dosing recommendations.
- Further research needed to establish optimal cannabis use for sleep.
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