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Ivermectin toxicosis in a dog.

D M Houston, J Parent, K J Matushek

    Journal of the American Veterinary Medical Association
    |July 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Ivermectin, an antiparasitic drug, caused severe central nervous system (CNS) dysfunction in a dog, including ataxia and a semicomatose state. Supportive care led to gradual recovery, highlighting potential ivermectin toxicity risks in canines.

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    Area of Science:

    • Veterinary Neurology
    • Pharmacology
    • Toxicology

    Background:

    • Ivermectin is a widely used broad-spectrum antiparasitic agent.
    • Central nervous system (CNS) dysfunction is a known potential adverse effect of ivermectin in some species.
    • Accurate diagnosis and management of ivermectin toxicity are crucial in veterinary medicine.

    Observation:

    • A dog presented with progressive hind limb ataxia within 2 hours of oral ivermectin administration.
    • Neurologic signs rapidly worsened, leading to a semicomatose state within 20 hours of admission.
    • The dog's clinical signs were consistent with ivermectin toxicosis.

    Findings:

    • The dog experienced severe CNS dysfunction attributed to ivermectin administration for suspected endoparasitism.

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  • Gradual improvement was observed under supportive care, suggesting the reversible nature of the toxic effects.
  • The case report documents a clear correlation between ivermectin exposure and the onset and progression of neurological signs.

    • Implications:

    • This case underscores the importance of careful ivermectin dosage and monitoring in dogs to prevent neurotoxicity.
    • Veterinarians should consider ivermectin toxicity in the differential diagnosis for dogs presenting with acute neurological deficits.
    • Further research into species-specific ivermectin sensitivity and safe dosing protocols is warranted.