Association between dysglycemia and the Charlson Comorbidity Index among hospitalized patients with diabetes

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Sara Atiq Khan1, Stephen Shields1, Mohammed S Abusamaan1

  • 1Division of Endocrinology, Diabetes, & Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.

Journal of Diabetes and Its Complications
|September 15, 2022
PubMed

Insights

Inpatient hyperglycemia and hypoglycemia increase one-year mortality risk in diabetes patients. Hypoglycemia showed a stronger association, suggesting diabetes complications may mediate this increased mortality risk.

Area of Science:

  • Endocrinology
  • Internal Medicine
  • Public Health

Background:

  • Inpatient dysglycemia (abnormal blood glucose) is linked to short-term mortality.
  • Longer-term mortality data for inpatient dysglycemia remain limited.

Purpose of the Study:

  • To investigate the association between inpatient dysglycemia and one-year mortality risk in adults with diabetes.

Main Methods:

  • Retrospective chart review of 22,639 adult diabetes admissions (2015-2019).
  • Charlson Comorbidity Index (CCI) used to stratify mortality risk (low: ≤5, high: ≥6).
  • Logistic regression analyzed associations between dysglycemic measures and high mortality risk.

Main Results:

  • Hyperglycemia (BG ≥180 mg/dL, ≥300 mg/dL) and hypoglycemia (BG ≤70 mg/dL, <54 mg/dL, <40 mg/dL) were associated with increased one-year mortality risk.
  • Hypoglycemia demonstrated a stronger association with mortality than hyperglycemia.
  • Older age and Black race were linked to both hyperglycemia and hypoglycemia.

Conclusions:

  • Both inpatient hypoglycemia and hyperglycemia are positively associated with increased one-year mortality.
  • The association between dysglycemia and mortality appears to be primarily mediated by diabetes-related complications.
Abstract

Keywords:
Charlson Comorbidity IndexHospitalHyperglycemiaHypoglycemiaMortality

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