Tonotopic evolution during development

The evolution of cochlear tonotopy can be observed by the study of the modification of tuning curves as obtained from auditory nerve fibers in the kitten. The differential development of the two components of the tuning curves, i.e. the tail, which is restricted to lower frequencies that appear at first during ontogenesis, and the tip which is restricted to higher frequencies that appear later, can explain the ontogenetic variations of tonotopy observed in the past. An hypothesis is presented where the tail of the tuning curve is related to the first functioning of the basal inner hair cells during development, whereas the delayed appearance of the tip is related to the basal outer hair cells. The base-apex gradient of maturation of receptors, along with their lateral gradient of development can explain the tonotopic shift observed during the cochlear ontogenesis.