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Related Experiment Video

Updated: Aug 28, 2025

Probiotic Studies in Neonatal Mice Using Gavage
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Feeding the preterm infant gut microbiota.

Samuli Rautava1

  • 1New Children's Hospital, Neonatal Intensive Care Unit, University of Helsinki & Helsinki University Hospital, Helsinki, Finland.

Cell Host & Microbe
|September 15, 2022
PubMed
Summary

Nutritional fortification of human milk for very preterm infants impacts gut microbiota development. This study compared human milk-based versus cow

Area of Science:

  • Neonatal nutrition
  • Microbiome research
  • Clinical outcomes in preterm infants

Background:

  • The gut microbiota plays a critical role in infant development and health.
  • Optimal nutritional strategies for very preterm neonates are crucial for their long-term well-being.
  • The impact of different milk fortifiers on the developing infant microbiome is not fully elucidated.

Purpose of the Study:

  • To investigate how nutritional management, specifically milk fortification, influences the gut microbiota composition in very preterm neonates.
  • To assess the association between specific microbiota profiles and clinical outcomes in this vulnerable population.
  • To compare the effects of human milk-based versus cow's milk-based fortifiers on infant microbiota.

Main Methods:

  • Randomized controlled trial design.

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  • Analysis of gut microbiota composition in very preterm infants.
  • Comparison of infants receiving human milk supplemented with human milk-based fortifier versus cow's milk-based fortifier.

    • Main Results:

    • Significant differences in gut microbiota composition were observed between the two fortification groups.
    • Specific microbial taxa were associated with different clinical outcomes.
    • The type of milk fortifier influenced the early-life gut microbiome trajectory.

    Conclusions:

    • Nutritional fortification strategies significantly shape the gut microbiota of very preterm infants.
    • Tailoring milk fortifiers may offer a pathway to optimize gut microbiome development and clinical outcomes.
    • Further research is warranted to elucidate the long-term implications of these findings.