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Related Experiment Video

Updated: Aug 28, 2025

Super-resolution Imaging of Proteus mirabilis Biofilm by Expansion Microscopy

Super-resolution Imaging of Proteus mirabilis Biofilm by Expansion Microscopy

Published on: July 18, 2025

SnapShot: The Expobiome Map.

Velma T E Aho¹, Marek Ostaszewski¹, Camille Martin-Gallausiaux²

¹Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.

Cell Host & Microbe

|September 15, 2022

Summary

This summary is machine-generated.

The human gut microbiome influences health and disease through immunogenic molecules. These "expobiome" components interact with immune pathways, contributing to chronic inflammatory conditions.

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Area of Science:

Microbiology
Immunology
Human Health

Background:

The human gut microbiome plays a crucial role in maintaining health and disease states.
Microbiome-derived molecules are increasingly recognized for their involvement in chronic inflammatory diseases.

Purpose of the Study:

To summarize the diverse range of immunogenic molecules produced by the gut microbiome.
To illustrate the interactions between these microbial molecules (the "expobiome") and human immune pathways in the context of chronic diseases.

Main Methods:

Literature review and synthesis of existing research on microbiome-derived immunogenic molecules.
Focus on categorizing molecules such as nucleic acids, (poly)peptides, structural components, and metabolites.
Examination of immune interactions within the framework of chronic disease pathogenesis.

Main Results:

Identification of diverse immunogenic molecules originating from the gut microbiome.
Detailed description of molecular classes including nucleic acids, peptides, structural elements, and metabolites.
Elucidation of specific interactions between these microbial molecules and host immune system pathways.

Conclusions:

The gut microbiome's expobiome significantly impacts host immunity.
Understanding these interactions is vital for comprehending and potentially treating chronic inflammatory diseases.
Further research into expobiome-host immune crosstalk holds therapeutic potential.