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Updated: Aug 28, 2025

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

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Risk Factors for Left Ventricular Thrombus Formation in Patients with Dilated Cardiomyopathy

Hao-Sheng Wu1, Jian-Zeng Dong1, Xin Du1

  • 1Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, People's Republic of China.

Seminars in Thrombosis and Hemostasis
|September 15, 2022
PubMed

Insights

Elevated D-dimer levels and reduced ejection fraction (EF) are linked to a higher risk of left ventricular thrombus (LVT) in dilated cardiomyopathy (DCM) patients. Severe mitral regurgitation may reduce LVT incidence.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Biomarkers

Background:

  • Left ventricular thrombus (LVT) is a significant complication of dilated cardiomyopathy (DCM), contributing to increased morbidity and mortality.
  • Understanding predictors of LVT is crucial for managing DCM patients.

Purpose of the Study:

  • To investigate the clinical characteristics associated with LVT in DCM patients.
  • To evaluate the diagnostic value of D-dimer in predicting LVT occurrence in DCM.

Main Methods:

  • Retrospective analysis of 3,134 DCM patients from January 2002 to August 2020.
  • Comparison of clinical characteristics between LVT and no-LVT groups, matched for age and sex.
  • Receiver operator characteristic (ROC) curve analysis to determine D-dimer's predictive value.

Main Results:

  • LVT was detected in 2.3% of patients.
  • Patients with LVT exhibited higher D-dimer and fibrinogen levels, lower systolic blood pressure, reduced ejection fraction (EF), and larger left ventricular end-systolic diameter.
  • An optimal D-dimer cut-off of 444 ng/mL DDU was identified; elevated D-dimer and reduced EF were independently associated with LVT.

Conclusions:

  • Elevated D-dimer levels (>444 ng/mL DDU) and reduced EF are independent predictors of LVT formation in DCM.
  • Severe mitral regurgitation (MR) was associated with a decreased incidence of LVT.
Abstract

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