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Lactate as substrate for glycogen resynthesis after exercise.

R W Stevenson, D R Mitchell, G K Hendrick

    Journal of Applied Physiology (Bethesda, Md. : 1985)
    |June 1, 1987
    PubMed
    Summary
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    Muscle glycogen resynthesis from lactate is possible but requires high blood lactate levels. Otherwise, lactate produced during exercise diffuses into the bloodstream.

    Area of Science:

    • Exercise Physiology
    • Biochemistry
    • Muscle Metabolism

    Background:

    • Muscle glycogen is a primary energy source during intense exercise.
    • Lactate accumulates in muscle during high-intensity contractions.
    • The fate of muscle lactate post-exercise is crucial for recovery.

    Purpose of the Study:

    • To investigate the potential for muscle glycogen resynthesis from accumulated lactate.
    • To determine the effect of perfusate lactate concentration on glycogen recovery.
    • To understand lactate's role in post-exercise muscle glycogen replenishment.

    Main Methods:

    • Perfused rat hemicorpus preparation subjected to electrical stimulation and epinephrine.
    • Muscle glycogen and lactate levels measured during and after exercise.

    Related Experiment Videos

  • Recovery perfusion with varying lactate concentrations (low vs. high) and no glucose.

    • Main Results:

    • Electrical stimulation and epinephrine significantly reduced muscle glycogen and increased lactate.
    • Low perfusate lactate during recovery led to lactate diffusion into the blood, with no glycogen resynthesis.
    • High perfusate lactate concentrations facilitated significant muscle glycogen resynthesis within 1 hour.
    • Extended recovery did not increase glycogen synthesis further.

    Conclusions:

    • Muscle glycogen resynthesis from lactate can occur post-exercise.
    • This process is dependent on high arterial lactate concentrations.
    • In the absence of high lactate, muscle lactate diffuses out, hindering glycogen replenishment.