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Hypoxia-induced changes in shivering and body temperature.

H Gautier, M Bonora, S A Schultz

    Journal of Applied Physiology (Bethesda, Md. : 1985)
    |June 1, 1987
    PubMed
    Summary

    Hypoxia suppresses shivering and lowers body temperature in cats, especially in the cold. Sinus nerve afferents help counteract this effect in intact cats at room temperature but not in the cold.

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    Area of Science:

    • Physiology
    • Environmental Medicine

    Background:

    • Thermoregulation is crucial for survival, especially during cold stress.
    • Hypoxia, a state of low oxygen, can significantly impact physiological responses.
    • The interplay between hypoxia, cold, and thermoregulation requires further elucidation.

    Purpose of the Study:

    • To investigate the effects of hypoxia on thermoregulation in conscious cats under cold stress.
    • To differentiate the roles of intact and carotid-denervated cats in responding to hypoxia.
    • To understand the central and peripheral mechanisms involved in hypoxia-induced thermoregulatory changes.

    Main Methods:

    • Experiments conducted on conscious intact and carotid-denervated cats.
    • Exposure to ambient and carbon monoxide (CO) hypoxia in both thermoneutral and cold environments.
    • Monitoring of shivering, body temperature, and physiological responses to varying oxygen and carbon dioxide levels.

    Main Results:

    • Hypoxia caused a prompt decrease in shivering and body temperature in both cat groups, particularly in the cold.
    • Carotid-denervated cats exhibited a greater reduction in shivering and body temperature compared to intact cats at equivalent oxygen levels.
    • Shivering returned during prolonged hypoxia but at reduced levels, leading to hypothermic stabilization; CO2 administration partially restored shivering.

    Conclusions:

    • Hypoxia acts centrally to suppress shivering, a response partially counteracted by sinus nerve afferents.
    • This counteraction is sufficient to maintain body temperature in intact cats at room temperature but not under cold stress.
    • Carotid denervation exacerbates the hypothermic effects of hypoxia, highlighting the role of peripheral chemoreceptors.

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