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Updated: Aug 28, 2025

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BMP and activin membrane-bound inhibitor regulate connective tissue growth factor controlling mesothelioma cell

Nguyen Truong Duc Hoang1, Ghmkin Hassan1, Tomoya Suehiro1

  • 1Department of Genomic Oncology and Oral Medicine, Graduate School of Biomedical and Health Science, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima-city, 834-8553, Japan.

BMC Cancer
|September 15, 2022
PubMed
Abstract

Insights

Connective tissue growth factor (CTGF) and bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI) promote malignant mesothelioma (MM) growth by driving cell cycle progression. Targeting their interaction may offer new MM treatment strategies.

Area of Science:

  • Oncology
  • Cancer Biology

Background:

  • Malignant mesothelioma (MM) is an aggressive cancer linked to asbestos exposure.
  • MM exhibits rapid progression and resistance to conventional therapies.
  • Tumor-derived connective tissue growth factor (CTGF) previously shown to regulate MM cell proliferation and tumor growth.

Purpose of the Study:

  • To investigate the relationship between bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI) and CTGF in MM.
  • To determine the impact of BAMBI and CTGF on MM cell cycle and proliferation.

Main Methods:

  • Knockdown of BAMBI and CTGF in MM cells.
  • Analysis of cell cycle regulators (cyclin D3, CDK2, CDK4) expression.
  • In silico analysis of BAMBI expression and patient survival rates.

Main Results:

  • Knockdown of either CTGF or BAMBI significantly reduced MM cell proliferation.
  • CTGF knockdown decreased BAMBI expression, while BAMBI knockdown increased CTGF levels.
  • Reduced expression of cyclin D3, CDK2, and CDK4 observed upon BAMBI or CTGF knockdown.
  • Higher BAMBI expression correlated with shorter overall survival in MM patients.

Conclusions:

  • BAMBI is regulated by CTGF, promoting mesothelioma growth through cell cycle progression.
  • The interplay between BAMBI and CTGF presents a potential therapeutic target for MM.
  • Targeting the BAMBI-CTGF axis could offer novel treatment strategies for malignant mesothelioma.
Keywords:
BAMBICTGFMalignant mesotheliomaProliferation; Cell cycle

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