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Updated: Aug 28, 2025
A High-throughput Automated Platform for the Development of Manufacturing Cell Lines for Protein Therapeutics
Published on: September 22, 2011
Status in molluscan cell line development in last one decade (2010-2020): impediments and way forward
Soumya Balakrishnan1, I S Bright Singh1, Jayesh Puthumana1
1National Centre for Aquatic Animal Health, Cochin University of Science and Technology, Cochin, Kerala 682016 India.
Abstract:
Despite the attempts that have started since the 1960s, not even a single cell line of marine molluscs is available. Considering the vast contribution of marine bivalve aquaculture to the world economy, the prevailing viral threats, and the dismaying lack of advancements in molluscan virology, the requirement of a marine molluscan cell line is indispensable. This synthetic review discusses the obstacles in developing a marine molluscan cell line concerning the choice of species, the selection of tissue and decontamination, and cell culture media, with emphasis given on the current decade 2010-2020. Detailed accounts on the experiments on the virus cultivation in vitro and molluscan cell immortalization, with a brief note on the history and applications of the molluscan cell culture, are elucidated to give a holistic picture of the current status and future trends in molluscan cell line development.
Supplementary Information:
The online version contains supplementary material available at 10.1007/s10616-022-00539-x.
