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Integrative medicine in treating post-stroke depression: Study protocol for a multicenter, prospective, randomized,

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Summary

This study investigates an integrative medicine approach combining traditional Chinese medicine, Western medicine, and rehabilitation for post-stroke depression (PSD). The findings will offer evidence for a standardized treatment plan to improve patient outcomes.

Keywords:
acupunctureintegrative medicinepost-stroke depressionrepeated transcranial magnetic stimulationtraditional Chinese medicine

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Area of Science:

  • Neurology
  • Psychiatry
  • Integrative Medicine

Background:

  • Post-stroke depression (PSD) is a common complication following stroke, increasing disability and mortality.
  • Current treatments include TCM, Western medicine, rehabilitation, and rTMS, but a comprehensive integrated plan is lacking.
  • This study addresses the need for an integrated treatment strategy for PSD.

Purpose of the Study:

  • To assess the efficacy and safety of an integrative medicine approach for treating PSD.
  • To develop and evaluate a comprehensive treatment plan integrating TCM, Western medicine, and rehabilitation.
  • To provide an evidence-based reference for standardized PSD treatment.

Main Methods:

  • A multicenter, prospective, randomized, controlled study involving 202 participants.
  • The integrative medicine group received acupuncture, Chinese herbs, and rTMS alongside standard care.
  • Standard care included basic treatment, nursing care, and exercise therapy.
  • Outcomes were measured using HAMD, SDS, ADL, MoCA, FMA, and PSQI at baseline, week 4, and week 8.

Main Results:

  • The study is designed to verify the efficacy and safety of the integrative medicine approach.
  • Primary outcomes include changes in depression and daily living activity scores.
  • Secondary outcomes assess cognitive function, motor function, and sleep quality.

Conclusions:

  • The study is expected to demonstrate the effectiveness of integrative medicine in managing PSD.
  • Findings will support the development of a standardized, evidence-based clinical protocol for PSD treatment.
  • This research aims to improve the quality of life for stroke survivors experiencing depression.