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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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Hyperhemolytic Crisis Following Transfusion in Sickle Cell Disease With Acute Hepatic Crisis: A Case Report

Krunal Trivedi1, Ahmed Abbas1, Riyashat Kazmi1

  • 1Internal Medicine, Saint Michael's Medical Center, Newark, USA.

Cureus
|September 16, 2022
PubMed

Hyperhemolysis syndrome (HHS) is a catastrophic unpredictable consequence of blood transfusion in sickle cell disease. It leads to further drop in hemoglobin via immune mechanisms complicating a hospital course and prolonging length of stay. Although sickle cell patients receive multiple transfusions throughout their disease course, this condition remains underreported by health care professionals or misinterpreted for other sickle cell crises. We present a similar case highlighting the importance of early recognition of HHS and judicious blood transfusion in sickle cell disease patients to avoid such a complication.

Keywords:
alloimmunizationhepatic crisishyperhemolytic crisissickle cell diseasetransfusion related complications

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