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Bromelain: A Potent Phytomedicine.

Paridhi Agrawal1, Pradnya Nikhade1, Aditya Patel2

  • 1Department of Conservative Dentistry and Endodontics, Sharad Pawar Dental College, Datta Meghe Institute of Medical Sciences, Sawangi, Wardha, IND.

Cureus
|September 16, 2022
PubMed
Summary

Bromelain, a protein-digesting enzyme from pineapple, offers numerous therapeutic benefits. This enzyme shows anti-inflammatory, anti-edematous, and anti-thrombotic effects, aiding various medical conditions.

Keywords:
antimicrobialbioactivebromelainbromelain enzymephytomedicine

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Area of Science:

  • Enzymology
  • Pharmacology
  • Biochemistry

Background:

  • Bromelain is a mixture of protein-digesting enzymes derived from pineapple.
  • Fruit and stem bromelain differ in composition and production methods.
  • It contains thiol endopeptidases, protease inhibitors, and other enzymes.

Purpose of the Study:

  • To review the properties and therapeutic applications of bromelain.
  • To explore the potential mechanisms of action for bromelain's effects.
  • To compile crucial traits and medical/dental uses of bromelain.

Main Methods:

  • Literature review of existing studies on bromelain.
  • Analysis of biochemical composition and enzymatic activities.
  • Compilation of reported therapeutic effects and mechanisms.

Main Results:

  • Bromelain exhibits fibrinolytic, anti-edematous, antithrombotic, and anti-inflammatory activities.
  • It is well-absorbed without loss of activity or adverse effects.
  • Therapeutic uses include wound healing, improved drug absorption, and management of inflammatory conditions.

Conclusions:

  • Bromelain possesses diverse therapeutic properties with significant medical and dental applications.
  • Its anti-inflammatory and proteolytic actions contribute to its efficacy.
  • Further research into its anti-cancer potential and mechanisms is warranted.