Related Experiment Video
Updated: Aug 28, 2025
08:36
Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
Published on: April 19, 2024
664
COVID Infections Breakthrough Post-Vaccination: Systematic Review
Syed Amaan Ali1, Shyamalima Bhattacharyya2, Faisal Noor Ahmad3
1Department of Periodontics and Community Dentistry, Dr. Ziauddin Ahmed Dental College and Hospital, Aligarh Muslim University, Aligarh, UP, India.
Journal of Pharmacy & Bioallied Sciences
|September 16, 2022
Summary
COVID-19 vaccination remains highly effective, with very low rates of breakthrough infections, especially among fully vaccinated individuals. This systematic review confirms vaccination
Area of Science:
- Immunology
- Epidemiology
- Public Health
Background:
- Emerging SARS-CoV-2 variants pose a risk of breakthrough infections in vaccinated populations.
- Reports indicate potential mortality even among vaccinated individuals, necessitating further investigation.
- Understanding infection breakthrough post-COVID-19 vaccination is crucial for public health strategies.
Purpose of the Study:
- To conduct a systematic review and meta-analysis of COVID-19 infection breakthrough in vaccinated individuals.
- To quantify the incidence of breakthrough infections after COVID-19 vaccination.
- To assess the impact of vaccination status (fully vs. partially vaccinated) on infection rates.
Main Methods:
- Systematic review and meta-analysis of online data sources.
- Inclusion of studies focusing on healthcare workers who completed COVID-19 vaccination.
- Enumeration and analysis of breakthrough infection data post-vaccination.
Main Results:
- Analysis of data from nearly 2.3 lakh subjects revealed less than 3% infection rates with new virus strains.
- Breakthrough infection rates were 1.2% for fully vaccinated individuals and 3.2% for partially vaccinated individuals.
- Partially vaccinated individuals exhibited a higher incidence of breakthrough infections.
Conclusions:
- Breakthrough infections following COVID-19 vaccination are notably low, particularly in fully vaccinated individuals.
- Vaccination significantly reduces the risk of infection and is strongly recommended to prevent mortality.
- The findings underscore the continued importance of COVID-19 vaccination programs.
Related Concept Videos
01:51Vaccinations
45.2K
Overview
45.2K
01:23Immunological Memory
3.6K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
3.6K
00:36Viral Mutations
32.8K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
32.8K
01:26Factors Affecting the Risk of Infection
12.2K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.2K
00:57Viral Recombination
23.7K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
23.7K
01:17Transmission-based Precautions I: Contact, Enteric, and Droplets
3.9K
Transmission-based precautions are for patients known to be infected or suspected to be infected or colonized with organisms that pose a significant risk to others. Some transmission-based precautions include contact, enteric, and droplet.
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
3.9K