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Updated: Aug 28, 2025

Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue
Published on: June 21, 2018
Lactate Dehydrogenase: The Beacon of Hope?
Anitha Krishnan Pandarathodiyil1, Anand Ramanathan2,3, Ranjana Garg1
1Faculty of Dentistry, SEGi University, Jalan Teknologi, Kota Damansara, Petaling Jaya, Selangor, Malaysia.
Abstract:
Lactate dehydrogenase enzyme (LDH) helps in the conversion of glucose into pyruvic acid during aerobic glycolysis and is found in the cytoplasm of most cells in the human body. When oxidative stress occurs in the body, LDH may be released extracellularly and its level is usually indicative of the severity of tissue damage. LDH has proved to be an inestimably resourceful marker in early prediction of serious diseases involving extensive tissue or cellular damage. This short communication explores the potential of LDH as a salivary biomarker of cell injury and death.
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