Related Experiment Video
Updated: Aug 28, 2025
Studying Orthodontic Tooth Movement in Mice
Published on: August 2, 2024
Association of Orthodontic Tooth Movement with Leptin Concentration in Gingival Crevicular Fluid
Manish Goutam1, Abhigyan Manas2, Arpita Kashyap3
1Department of Prosthodontics, Dental Institute, Rajendra Institute of Medical Sciences, Ranchi, Jharkand, India.
Objectives:
This study aims to evaluate the association of orthodontic tooth movement with the concentration of leptin in gingival crevicular fluid (GCF).
Materials And Methods:
In thirty orthodontic patients, the concentration of leptin was assessed at baseline, 1 h, 24 h, 7 days, and 1 month after application of orthodontic force. Distalized tooth movement was evaluated by measuring the difference on dental casts at baseline and 1 month after force application.
Results:
Average concentration of leptin in GCF raises from baseline (T0) to 1 h after application of force (T1). There was a significant association of the overall average concentration of leptin with the degree of tooth movement (correlation coefficient = 0.625).
Conclusion:
There was a biphasic change in GCF leptin concentration and significant association between rates of tooth movement with GCF leptin concentration.
