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Biomarkers in oral immunotherapy
Haitao Zhu1, Kaifa Tang2, Guoqiang Chen1
1Department of Pediatrics (No. 3 Ward), Northwest Women's and Children's Hospital, Xi'an 710061, China.
Journal of Zhejiang University. Science. B
|September 16, 2022
Summary
Effective treatment for food allergy (FA) is crucial. Oral immunotherapy (OIT) shows promise, but reliable biomarkers are needed to assess treatment effectiveness and predict outcomes in FA patients.
Area of Science:
- Immunology
- Allergology
- Clinical Medicine
Background:
- Food allergy (FA) presents a significant global health challenge.
- Oral immunotherapy (OIT) is an emerging treatment for FA, demonstrating efficacy and safety.
- Reliable biomarkers are essential for monitoring OIT progress and predicting patient outcomes.
Purpose of the Study:
- To review and evaluate the utility of various immunological indicators as biomarkers for OIT in food allergy.
- To discuss current and potential novel biomarkers for assessing OIT effectiveness.
Main Methods:
- Literature review of immunological indicators used in OIT for FA.
- Assessment of established biomarkers like skin prick tests, cellular reactivity, and antibody levels.
- Exploration of novel indicators as potential biomarkers.
Main Results:
- Several immunological markers, including skin tests, cellular assays, and antibody levels, are utilized in OIT.
- These biomarkers aid in assessing treatment response and predicting outcomes.
- Novel indicators show potential for enhanced OIT monitoring.
Conclusions:
- Immunological biomarkers are vital for the assessment and prediction of outcomes in OIT for food allergy.
- A comprehensive understanding of these biomarkers is crucial for optimizing FA treatment strategies.
