Three new coumarin derivatives from Maytenus hookeri
Lingjie Meng1,2,3, Changyan Yu1,2,3, Jing Hui1,2,3
1Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, Zunyi, China.
Abstract:
Three new coumarin derivatives named maytenucoums A-C (1-3), along with six known analogs (4-9), were isolated from the branches of Maytenus hookeri. Their structures were determined by comprehensive spectroscopic data analysis, including NMR and HR-ESIMS. In the preliminary assays, compound 4 showed cytotoxic activity against the A549, SK-Hep1 and HCT116 cells with IC50 values of 29.0, 28.6 and 54.4 μM, respectively.
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